|
|
| Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
06/10/2017 |
Data da última atualização: |
22/12/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
GHIZONI, C. V. C.; AMES, A. P. A.; LAMEIRA, O. A.; AMADO, C. A. B.; NAKANISHI, A. B. S.; BRACHT, L.; NATALI, M. R. M.; PERALTA, R. M.; BRACHT, A.; COMAR, J. F. |
Afiliação: |
Cristiane V. Castro Ghizoni, UEM; Ana P. Arssufi Ames, UEM; OSMAR ALVES LAMEIRA, CPATU; Ciomar A. Bersani Amado, UEM; Anacharis B. Sá Nakanishi, UEM; Lívia Bracht, UEM; Maria R. Marçal Natali, UEM; Rosane M. Peralta, UEM; Adelar Bracht, UEM; Jurandir F. Comar, UEM. |
Título: |
Anti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of Cellular Biochemistry, v. 118, n. 10, p. 3409-3423, 2017. |
DOI: |
10.1002/jcb.25998 |
Idioma: |
Inglês |
Conteúdo: |
The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J. MenosThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. Th... Mostrar Tudo |
Palavras-Chave: |
Toxicidade. |
Thesagro: |
Copaíba; Fígado; Metabolismo; Óleo. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
Marc: |
LEADER 02525naa a2200301 a 4500 001 2076843 005 2021-12-22 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1002/jcb.25998$2DOI 100 1 $aGHIZONI, C. V. C. 245 $aAnti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats.$h[electronic resource] 260 $c2017 520 $aThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J. 650 $aCopaíba 650 $aFígado 650 $aMetabolismo 650 $aÓleo 653 $aToxicidade 700 1 $aAMES, A. P. A. 700 1 $aLAMEIRA, O. A. 700 1 $aAMADO, C. A. B. 700 1 $aNAKANISHI, A. B. S. 700 1 $aBRACHT, L. 700 1 $aNATALI, M. R. M. 700 1 $aPERALTA, R. M. 700 1 $aBRACHT, A. 700 1 $aCOMAR, J. F. 773 $tJournal of Cellular Biochemistry$gv. 118, n. 10, p. 3409-3423, 2017.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Amazônia Oriental (CPATU) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
Registro Completo
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
18/03/2009 |
Data da última atualização: |
30/01/2018 |
Tipo da produção científica: |
Folder/Folheto/Cartilha |
Autoria: |
LOPES, A. de M.; ROCHA NETO, O. G. da; SOUZA, V. B. (coord.). |
Afiliação: |
ALTEVIR DE MATOS LOPES, CPATU; OLINTO GOMES DA ROCHA NETO, CPATU; VLADIMIR BOMFIM SOUZA, CPATU. |
Título: |
Unidade demonstrativa de arroz cultivar BRS Monarca: Fazenda Poderosa - Rodovia PA 125 Km 23 Paragominas - Pará. |
Ano de publicação: |
2008 |
Fonte/Imprenta: |
Belém, PA: Embrapa Amazônia Oriental, 2008. |
Idioma: |
Português |
Notas: |
1 folder. |
Palavras-Chave: |
Brasil; BRS Monarca; Pará; Paragominas. |
Thesagro: |
Arroz; Doença de Planta; Oryza Sativa; Variedade. |
Thesaurus NAL: |
Amazonia; rice. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/87772/1/Digitalizar0063.pdf
|
Marc: |
LEADER 00695nam a2200253 a 4500 001 1410060 005 2018-01-30 008 2008 bl uuuu u0uu1 u #d 100 1 $aLOPES, A. de M. 245 $aUnidade demonstrativa de arroz cultivar BRS Monarca$bFazenda Poderosa - Rodovia PA 125 Km 23 Paragominas - Pará. 260 $aBelém, PA: Embrapa Amazônia Oriental$c2008 500 $a1 folder. 650 $aAmazonia 650 $arice 650 $aArroz 650 $aDoença de Planta 650 $aOryza Sativa 650 $aVariedade 653 $aBrasil 653 $aBRS Monarca 653 $aPará 653 $aParagominas 700 1 $aROCHA NETO, O. G. da 700 1 $aSOUZA, V. B.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Amazônia Oriental (CPATU) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Expressão de busca inválida. Verifique!!! |
|
|